Book cover of Why Zebras Don't Get Ulcers by Robert M. Sapolsky

Why Zebras Don't Get Ulcers

by Robert M. Sapolsky

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Introduction

In our fast-paced modern world, stress has become an almost universal experience. We're constantly bombarded with advice on how to manage it, from productivity hacks to mindfulness practices. But what exactly is stress, and how does it affect our bodies, minds, and societies? Robert M. Sapolsky's book "Why Zebras Don't Get Ulcers" takes a comprehensive look at these questions, exploring the biology of stress and its wide-ranging impacts on human health and well-being.

The title of the book hints at a key insight: unlike zebras on the African savannah, humans have evolved complex brains that allow us to feel and create stress in response to a wide variety of situations, including imagined future problems. This makes us susceptible to chronic stress in a way that other mammals are not. The consequences of this chronic stress are far-reaching, affecting our cardiovascular system, insulin production, reproductive health, and overall well-being.

Sapolsky's book is a journey through the intricate workings of our stress response system, offering insights into how stress impacts various aspects of our health and providing guidance on how we can better manage and cope with stress in our lives. Let's dive into the key ideas presented in this fascinating exploration of stress and its effects.

The Origins and Nature of Stress

Stress as a Response to Physical Crises

To understand stress, we need to look at its evolutionary origins. In the animal kingdom, stress responses are typically activated by immediate physical dangers or risks. Picture a zebra on the savannah, fleeing from a lion. This is a classic stress-inducing situation – a life-or-death crisis that requires immediate action for survival.

For animals in the wild, stress is usually short-lived and directly related to physical threats or challenges. Once the danger has passed or the challenge has been met, the stress response subsides, and the animal returns to a state of relative calm.

Human Stress: Beyond Physical Threats

Humans, however, have evolved to experience stress in response to a much wider range of situations, many of which are psychological rather than physical in nature. We get stressed about traffic jams, work deadlines, arguments with loved ones, and countless other situations that don't pose immediate physical danger.

What's more, humans have the unique ability to stress about potential future events. We worry about our mortgages, upcoming job interviews, retirement savings, and other hypothetical scenarios. This capacity for anticipatory stress is a double-edged sword. On one hand, it allows us to plan for and potentially avoid future problems. On the other hand, it can lead to chronic stress over situations we may have little control over.

This sustained psychological stress is a relatively recent phenomenon in evolutionary terms. Our bodies' stress response systems, which evolved to deal with immediate physical threats, are now constantly activated by the psychological stressors of modern life. This mismatch between our ancient stress response and our current environment is at the root of many stress-related health problems.

The Biology of Stress

The Autonomic Nervous System: Our Stress Control Center

To understand how stress affects us, we need to look at the system that manages our stress response: the autonomic nervous system. This system controls all the involuntary functions of our body, from breathing and heart rate to digestion and sexual arousal.

The autonomic nervous system is divided into two main branches that work in opposition to each other:

  1. The Sympathetic Nervous System: This is often called the "fight or flight" system. It kicks into gear during emergencies, real or perceived. It's responsible for the immediate stress response, increasing heart rate, dilating pupils, and directing blood flow to the muscles.

  2. The Parasympathetic Nervous System: This is sometimes called the "rest and digest" system. It promotes calm, growth, energy storage, and other restorative processes.

These two systems work in a dynamic balance, constantly adjusting our body's state in response to our environment and experiences. The sympathetic system can be activated incredibly quickly – crucial for survival in the face of immediate threats. The parasympathetic system, on the other hand, helps us return to a state of calm and promotes long-term health and well-being.

Hormones and Long-Term Stress Effects

In addition to the immediate responses controlled by the nervous system, stress also triggers the release of various hormones into the bloodstream. While slower to act than the nervous system responses, these hormones have longer-lasting effects throughout the body.

The primary stress hormones are cortisol and adrenaline. These hormones help mobilize energy resources and prepare the body for action. However, when stress becomes chronic, consistently elevated levels of these hormones can have detrimental effects on health.

The Body's Response to Stress

Prioritizing Short-Term Survival

When we're under stress, our body shifts into a mode that prioritizes immediate survival over long-term health. This makes sense from an evolutionary perspective – if you're being chased by a predator, your body's resources are better spent on running away than on processes like digestion or tissue repair.

Here's what happens in the body during a stress response:

  1. Energy Mobilization: Glucose and fat are moved from storage into the bloodstream, providing quick energy for muscles.

  2. Increased Cardiovascular Activity: Heart rate, blood pressure, and breathing all increase to transport nutrients and oxygen more quickly.

  3. Enhanced Cognitive and Sensory Skills: Our senses become sharper, and we become more alert and focused.

  4. Suppression of Non-Essential Functions: Processes like digestion, growth, and immune function are temporarily put on hold to conserve energy.

The Cost of Chronic Stress

While these responses are helpful in the short term, they can be harmful if activated too frequently or for too long. Chronic stress essentially keeps our body in a constant state of emergency, which can lead to a range of health problems:

  1. Fatigue: Constantly mobilizing energy resources leaves us feeling tired and drained.

  2. Digestive Issues: Suppressed digestive function can lead to problems like ulcers.

  3. Weakened Immune System: With immune function suppressed, we become more vulnerable to infections and diseases.

  4. Impaired Growth and Repair: The body's ability to heal and maintain itself is compromised.

Understanding these processes helps us appreciate why chronic stress can have such wide-ranging effects on our health. In the following sections, we'll explore some of these effects in more detail.

Stress and Cardiovascular Health

The Pressure Cooker Effect

One of the most significant ways stress affects our health is through its impact on the cardiovascular system. When we're stressed, our blood vessels constrict and our heart rate increases, pushing blood through our system at a higher speed and pressure.

This is like turning up the pressure in a garden hose. The increased pressure and speed of blood flow can, over time, damage the walls of our blood vessels. In response, the body builds more muscle around these vessels to help control the flow. However, this makes the vessels more rigid, which in turn increases blood pressure even further. It's a vicious cycle that can lead to chronic high blood pressure, or hypertension.

The Danger of Blood Clots

Another risk of this high-pressure blood flow is the formation of blood clots. The rapid flow of blood can create inflammation at branch points in blood vessels, leading to the formation of clots. These clots can break loose and travel through the bloodstream, potentially blocking smaller blood vessels.

If a clot blocks a coronary artery, it can cause a heart attack. If it blocks a blood vessel in the brain, it can lead to a stroke. This is why stress is a significant risk factor for cardiovascular diseases, which are the leading cause of death in many countries.

Long-Term Cardiovascular Risks

Chronic stress essentially puts our cardiovascular system under constant strain. Over time, this can lead to:

  1. Atherosclerosis: The hardening and narrowing of arteries due to the buildup of plaque.

  2. Hypertension: Chronic high blood pressure, which puts additional strain on the heart and blood vessels.

  3. Increased Risk of Heart Attack and Stroke: Due to the combined effects of hypertension, atherosclerosis, and increased likelihood of blood clots.

  4. Weakened Heart Muscle: Constant overwork can lead to the heart muscle becoming enlarged and less efficient.

These effects highlight why managing stress is crucial for maintaining cardiovascular health. Regular exercise, a healthy diet, and stress-reduction techniques can all help mitigate these risks.

Stress and Metabolic Health

The Energy Mobilization Problem

When we're stressed, our body mobilizes energy resources to prepare for action. Glucose and fatty acids are released into the bloodstream, ready to fuel our muscles. This is great if we actually need to run from a predator or engage in intense physical activity. But what happens when the stress is psychological, and we don't use up that energy?

In these cases, the nutrients are often reabsorbed into storage. This process of releasing and reabsorbing nutrients is itself energy-consuming. If we're constantly stressing over minor issues, our body wastes a lot of energy on this back-and-forth process, leading to fatigue and potentially contributing to metabolic disorders.

The Link Between Stress and Diabetes

Chronic stress can increase the risk of developing diabetes, particularly Type 2 diabetes. Here's how:

  1. Insulin Resistance: Constant high levels of stress hormones like cortisol can make cells less responsive to insulin, the hormone that helps cells absorb glucose from the bloodstream.

  2. Increased Glucose Production: Stress hormones stimulate the liver to produce more glucose, potentially leading to chronically elevated blood sugar levels.

  3. Fat Distribution: Chronic stress can lead to increased abdominal fat, which is associated with insulin resistance and increased diabetes risk.

  4. Inflammation: Stress promotes inflammation in the body, which is linked to insulin resistance and the development of diabetes.

The Vicious Cycle of Stress and Diabetes

For people who already have diabetes, stress can make managing the condition more difficult:

  1. Blood Sugar Fluctuations: Stress hormones can cause blood sugar levels to rise, making it harder to maintain good glycemic control.

  2. Behavioral Changes: Stress can lead to poor eating habits, less physical activity, and forgetting to take medications, all of which can worsen diabetes management.

  3. Increased Complications: The combination of stress and poorly controlled diabetes can accelerate the development of diabetes-related complications, such as cardiovascular disease and kidney problems.

Understanding these connections underscores the importance of stress management as part of a comprehensive approach to metabolic health and diabetes prevention and management.

Stress and Mental Health

The Stress-Depression Connection

One of the most profound ways that stress affects our health is through its impact on mental health, particularly in relation to depression. Depression is a serious condition characterized by persistent feelings of sadness, hopelessness, and loss of interest in activities. It's projected to be the second-leading cause of medical disability globally by 2020, highlighting its significant impact on individuals and society.

Interestingly, the changes that occur in the brain and behavior of a depressed person are remarkably similar to those experienced by someone under chronic stress. Here are some key connections:

  1. Neurotransmitter Depletion: Stress depletes dopamine in the brain's pleasure pathways, making it harder to experience pleasure. This mirrors the anhedonia (inability to feel pleasure) that's a hallmark of depression.

  2. Learned Helplessness: Chronic stress can lead to a state of learned helplessness, where individuals feel they have no control over their situation. This is also a common feature of depression.

  3. Cognitive Changes: Both stress and depression can lead to difficulties with concentration, memory, and decision-making.

  4. Sleep Disturbances: Stress often disrupts sleep patterns, as does depression.

  5. Physical Symptoms: Both conditions can manifest physical symptoms like fatigue, changes in appetite, and various aches and pains.

The Role of Stress in Depression Development

While not everyone who experiences stress will develop depression, chronic stress is a significant risk factor for the condition. Here's how stress can contribute to the development of depression:

  1. Neuroplasticity: Chronic stress can alter brain structure and function, particularly in areas involved in mood regulation.

  2. HPA Axis Dysregulation: Stress affects the hypothalamic-pituitary-adrenal (HPA) axis, which regulates stress responses. Dysregulation of this system is associated with depression.

  3. Inflammation: Chronic stress promotes inflammation in the body and brain, which is increasingly recognized as a factor in depression.

  4. Social Isolation: Stress can lead to social withdrawal, which in turn increases the risk of depression.

  5. Coping Mechanisms: Unhealthy stress coping mechanisms, like substance abuse, can increase depression risk.

Stress and Recovery from Trauma

Stress also plays a crucial role in how we recover from traumatic experiences. High levels of stress can make it more difficult to process and recover from trauma, potentially leading to conditions like post-traumatic stress disorder (PTSD).

When we're under chronic stress, our ability to cope with additional stressors is diminished. This can make traumatic experiences even more impactful and harder to recover from. Additionally, the physiological changes induced by chronic stress can interfere with the brain's natural recovery processes following trauma.

Understanding these connections between stress and mental health underscores the importance of stress management not just for physical health, but for mental well-being as well. Techniques like mindfulness, cognitive-behavioral therapy, and regular exercise can help manage stress and potentially reduce the risk of stress-related mental health issues.

Stress and Reproductive Health

The Delicate Balance of Reproduction

Our reproductive system is intricately connected to our overall health and well-being, and it's particularly susceptible to the effects of stress. Both men and women can experience significant impacts on their reproductive health and sexual function due to chronic stress.

Stress and Male Reproductive Health

For men, stress can affect sexual function in several ways:

  1. Erectile Dysfunction: The process of achieving an erection is managed by the parasympathetic nervous system, which is responsible for "rest and digest" functions. Stress activates the opposing sympathetic system, making it harder to achieve and maintain an erection.

  2. Premature Ejaculation: Stress can lead to increased muscle tension and heightened nervous system arousal, potentially contributing to premature ejaculation.

  3. Reduced Libido: Chronic stress can lower testosterone levels, which can decrease sex drive.

  4. Fertility Issues: Stress can affect sperm production and quality, potentially impacting fertility.

  5. Performance Anxiety: The stress of sexual performance itself can create a vicious cycle, where anxiety about performance leads to difficulties, which in turn increases anxiety.

Stress and Female Reproductive Health

For women, stress can have wide-ranging effects on reproductive health:

  1. Menstrual Irregularities: Stress can disrupt the delicate hormonal balance that regulates the menstrual cycle, leading to irregular periods.

  2. Decreased Libido: Stress can lower estrogen levels, which can reduce sexual desire and arousal.

  3. Fertility Problems: Chronic stress can interfere with ovulation and make it more difficult to conceive.

  4. Pregnancy Complications: High stress levels during pregnancy have been associated with increased risk of complications like preterm birth and low birth weight.

  5. Worsened Menopausal Symptoms: Stress can exacerbate the symptoms of menopause, such as hot flashes and mood swings.

The Hormonal Connection

The link between stress and reproductive health largely comes down to hormones. Stress triggers the release of cortisol, often called the "stress hormone." High levels of cortisol can interfere with the production and regulation of sex hormones like estrogen and testosterone.

In women, stress can disrupt the hypothalamic-pituitary-ovarian axis, which regulates the menstrual cycle and ovulation. This can lead to irregular periods, reduced fertility, and exacerbation of conditions like polycystic ovary syndrome (PCOS).

In men, chronic stress can lower testosterone levels, affecting everything from libido to sperm production. It can also increase levels of prolactin, a hormone that can interfere with sexual function.

The Psychological Factor

Beyond the physiological effects, stress can also impact reproductive health through psychological means. Stress often leads to fatigue, irritability, and mood swings, which can strain relationships and reduce interest in sexual activity. It can also contribute to anxiety and depression, which are themselves linked to sexual dysfunction.

Moreover, issues with sexual function or fertility can become significant sources of stress in themselves, creating a feedback loop that further exacerbates the problem.

Breaking the Cycle

Given the significant impact of stress on reproductive health, managing stress is crucial for maintaining sexual well-being and fertility. This might involve:

  1. Stress reduction techniques like meditation or yoga
  2. Regular exercise, which can help reduce stress and boost sexual health
  3. Open communication with partners about stress and its effects
  4. Seeking professional help when needed, whether from a mental health professional or a sexual health specialist

By understanding and addressing the links between stress and reproductive health, individuals can take proactive steps to protect their sexual well-being and fertility.

The Social Dimensions of Stress

Stress and Socioeconomic Status

While stress is a universal human experience, it's not experienced equally by all members of society. Socioeconomic status plays a significant role in both the amount of stress a person experiences and their ability to cope with that stress.

People living in poverty often face numerous stressors:

  1. Job Insecurity: Low-wage jobs often come with little job security, creating constant stress about potential job loss.

  2. Financial Strain: The constant worry about making ends meet is a significant source of chronic stress.

  3. Poor Living Conditions: Substandard housing, lack of access to green spaces, and exposure to environmental pollutants can all contribute to stress.

  4. Limited Access to Healthcare: This can lead to untreated health issues, which become additional sources of stress.

  5. Higher Crime Rates: Living in high-crime areas creates a constant background of stress and fear.

These stressors don't just affect adults. Children growing up in poverty are exposed to higher levels of stress, which can have long-lasting effects on their physical and mental health.

The Long-Term Impact of Childhood Poverty

Interestingly, the effects of poverty-induced stress can persist even after an individual's economic situation improves. A study of elderly nuns who had entered the convent at a young age found that the socioeconomic conditions they grew up in influenced their health patterns in old age, despite having lived in identical conditions for 50 years.

This suggests that early-life stress can have profound and long-lasting effects on health, highlighting the importance of addressing childhood poverty as a public health issue.

Relative Poverty and Stress

It's not just absolute poverty that matters when it comes to stress. Relative poverty – feeling poor compared to those around you – can be just as stressful. This is where the concept of subjective socioeconomic status comes into play.

Subjective socioeconomic status measures how a person perceives their standard of living and financial security compared to their peers. Studies in wealthy countries have shown that once a certain standard of living is reached, it's not the absolute amount of money in your bank account that matters most for stress levels, but how you perceive your financial well-being compared to others.

This helps explain why even relatively wealthy individuals can experience high levels of stress if they feel they're not keeping up with their peers.

Income Inequality and Social Stress

On a societal level, income inequality is associated with higher stress levels and poorer health outcomes for everyone, not just the poor. Here's why:

  1. Lack of Trust: High income inequality tends to erode social trust, leading to more stress in daily interactions.

  2. Reduced Social Cohesion: When there's a wide gap between rich and poor, it's harder for people to feel a sense of shared community.

  3. Increased Crime: Income inequality is associated with higher crime rates, which increases stress for all members of society.

  4. Political Polarization: Large wealth gaps can lead to political divisions, creating a tense social atmosphere.

Interestingly, in societies with better income equality, both the rich and poor tend to be healthier. The rich benefit from living in a more cohesive, less hostile society, while the poor benefit from better access to resources and opportunities.

Social Capital and Stress

On the positive side, communities with high social capital tend to have better health outcomes and lower stress levels. Social capital refers to the networks of relationships that help a society function effectively. It includes things like:

  1. Trust between community members
  2. Strong social networks and support systems
  3. Civic engagement and community participation
  4. Shared norms and values

Communities with high social capital tend to have:

  1. Better diffusion of health information
  2. Lower levels of social isolation
  3. Greater feelings of safety and security
  4. More resources to draw upon in times of need

All of these factors can help reduce stress and improve overall health outcomes.

The Importance of Social Support

Both giving and receiving social support can be powerful stress reducers. Having a strong support network – friends, family, or community members you can turn to in times of need – can significantly buffer the effects of stress.

Interestingly, providing support to others can be just as beneficial for stress reduction as receiving it. This might explain why married people tend to be healthier on average than single people – they both give and receive emotional support on a regular basis.

Similarly, people in professions that involve providing valuable social services (like judges or healthcare workers) often report high levels of job satisfaction and tend to be healthier in old age, despite the stressful nature of their work.

Stress and Public Policy

Understanding the social dimensions of stress has important implications for public policy. Efforts to reduce income inequality, improve social cohesion, and build social capital can have far-reaching effects on public health by reducing overall stress levels in society.

Policies that might help include:

  1. Progressive taxation and strong social safety nets to reduce income inequality
  2. Investment in public spaces and community programs to build social capital
  3. Early childhood interventions to mitigate the effects of poverty on children
  4. Workplace policies that promote work-life balance and reduce job-related stress

By addressing stress not just as an individual health issue but as a social and societal concern, we can work towards creating healthier, more resilient communities.

Coping with Stress: Strategies for Better Health

Understanding Your Stress Response

The first step in better managing stress is understanding your own stress response. Everyone reacts to stress differently, and what's stressful for one person might not be for another. Pay attention to your physical and emotional reactions to different situations. Do you get headaches? Feel irritable? Have trouble sleeping? Identifying your stress symptoms can help you recognize when you need to implement coping strategies.

Taking Control Where You Can

One effective way to reduce stress is to take control of the situations you can influence. This doesn't mean trying to control everything – that's a recipe for more stress. Instead, focus on the aspects of your life where you can make positive changes.

For example, if you're stressed about a big project at work, break it down into smaller, manageable tasks. Set realistic goals and deadlines for yourself. This approach can help you feel more in control and less overwhelmed.

The Power of Perception

Sometimes, the most effective way to deal with stress is to change how you perceive a situation. This doesn't mean ignoring real problems, but rather reframing them in a way that's less stressful.

For instance, if you're stressed about a job interview, instead of thinking "I'll probably fail," try reframing it as "This is an opportunity to showcase my skills and learn more about the company." This shift in perspective can reduce anxiety and help you perform better.

The Importance of Social Support

As we discussed earlier, social support is a powerful buffer against stress. Cultivate and maintain strong relationships with family, friends, and community members. Don't be afraid to reach out when you need help or support.

Remember, providing support to others can be just as beneficial as receiving it. Volunteering or helping a friend in need can give you a sense of purpose and connection that reduces your own stress levels.

Physical Activity and Stress Reduction

Regular exercise is one of the most effective stress-reduction techniques available. Physical activity helps burn off stress hormones like cortisol and adrenaline, and it promotes the release of endorphins, the body's natural mood elevators.

You don't need to become a gym rat to benefit. Even moderate activities like brisk walking, gardening, or dancing can help reduce stress. The key is to find activities you enjoy and make them a regular part of your routine.

Mindfulness and Relaxation Techniques

Practices like mindfulness meditation, deep breathing exercises, and progressive muscle relaxation can help calm your mind and body. These techniques can lower your heart rate, reduce muscle tension, and help you feel more centered and less stressed.

Even a few minutes of mindful breathing each day can make a difference. Try incorporating these practices into your daily routine, perhaps first thing in the morning or during a mid-day break.

Healthy Lifestyle Habits

Managing stress isn't just about what you do when you're feeling stressed – it's also about creating a lifestyle that makes you more resilient to stress. This includes:

  1. Getting enough sleep: Lack of sleep can increase stress levels and make it harder to cope with stressors.

  2. Eating a balanced diet: A healthy diet can help stabilize your mood and give you the energy you need to deal with stress.

  3. Limiting caffeine and alcohol: While these substances might seem to help in the short term, they can increase anxiety and disrupt sleep, making stress worse in the long run.

  4. Practicing good time management: Feeling constantly rushed or behind schedule is a major source of stress for many people. Learning to manage your time effectively can reduce this source of stress.

Seeking Professional Help

If you're finding it difficult to manage stress on your own, don't hesitate to seek professional help. A mental health professional can provide you with additional coping strategies and help you work through underlying issues that might be contributing to your stress.

Therapy approaches like cognitive-behavioral therapy (CBT) can be particularly effective for stress management. CBT helps you identify and change thought patterns that contribute to stress and anxiety.

Creating Stress-Reducing Environments

Where possible, try to create environments that reduce stress rather than contribute to it. This might mean:

  1. Decluttering your living space to create a sense of calm and order
  2. Setting boundaries around work hours if you work from home
  3. Creating a relaxing bedtime routine to improve sleep quality
  4. Spending time in nature, which has been shown to reduce stress levels

The Importance of Self-Care

Finally, remember the importance of self-care. This doesn't mean indulging in expensive spa treatments (unless that's what works for you). Self-care is about taking the time to do things that nourish your physical, emotional, and spiritual well-being.

This could be as simple as taking a relaxing bath, reading a book for pleasure, practicing a hobby, or spending quality time with loved ones. The key is to regularly engage in activities that help you feel renewed and refreshed.

Conclusion: The Path to Better Stress Management

As we've explored throughout this summary, stress is a complex phenomenon with far-reaching effects on our physical and mental health. From its evolutionary origins as a survival mechanism to its role in modern psychological distress, stress touches every aspect of our lives.

We've seen how stress affects our cardiovascular system, potentially leading to heart disease and stroke. We've explored its impact on our metabolic health, including its role in the development of diabetes. We've delved into the intricate connections between stress and mental health, particularly depression. And we've examined how stress influences our reproductive health and sexual function.

Moreover, we've looked beyond individual experiences to understand the social dimensions of stress. We've seen how socioeconomic status, income inequality, and social capital all play crucial roles in determining stress levels and health outcomes across society.

But despite the pervasive nature of stress in modern life, we're not helpless in the face of it. By understanding the mechanisms of stress, we can develop more effective strategies to manage it. From taking control of situations we can influence, to changing our perceptions of stressful events, to cultivating strong social support networks, we have many tools at our disposal.

Physical activity, mindfulness practices, and healthy lifestyle habits all play important roles in building resilience to stress. And when our own resources aren't enough, professional help is available to provide additional support and strategies.

The key takeaway from "Why Zebras Don't Get Ulcers" is that while we can't eliminate stress from our lives entirely, we can learn to manage it more effectively. By doing so, we can mitigate its negative health effects and lead happier, healthier lives.

Remember, stress management is not a one-size-fits-all proposition. What works for one person may not work for another. The journey to better stress management is a personal one, requiring self-reflection, experimentation, and patience.

As you move forward, consider how you can apply the insights from this book to your own life. Perhaps you'll start a regular exercise routine, practice mindfulness meditation, or work on building stronger social connections. Maybe you'll reassess your work-life balance or seek professional help to develop more effective coping strategies.

Whatever path you choose, remember that managing stress is an ongoing process, not a destination. Be patient with yourself, celebrate small victories, and keep working towards a healthier, less stressed you. After all, while we may not be zebras, we all deserve to live without the burden of chronic stress and its damaging effects on our health and happiness.

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